Areas of use

can be used in all areas where electrophysiological measurements are done today. In the area of ion channels and membrane transporters today this includes

 

Target identification and validation
Pharmacology Screening
Drug safety / early ADME-Tox

 

Furthermore the new possibilities offered with advanced bilayer techniques open new insights in novel areas of reseach. The combined observation of e.g. binding events and electrical currents provides the chance to elucidate

  • the general influence of specific effectors binding to biomembranes (such as prions and synucleins).
  • that certain biomolecules of not fully understood function alter membrane conductivity by binding to them.

 

© copyright by Ionovation GmbH, Osnabrück, 2004-2010

 


Applications (pdf):

 

Channels and Transporters measured using a Ionotec setup:

  • Sec61p complex
  • OEP21 anion selective chloroplast solute channel
  • plastid envelope preprotein conducting channel
  • Toc75 chloroplast protein import channel
  • Tim22 mitochondrial protein insertion complex
  • Tim23 mitochondrial preprotein translocase
  • Ca(2+)- and voltage-modulated flagellar ion channel
  • OEP16 outer chloroplast envelope protein
  • K+-channel from Streptomyces lividans
  • and many more ...
  •