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In membrane biology, electrophysiology is one of the central investigation tools. In the past the standard technological approach has primarily consisted of the various alterations of patch clamping of membranes and cells. However, certain limitations with respect to flexibility, throughput, userfriendliness, and information content have become obvious over the years.
Now there is an alternative to conventional methods: The Ionovation Compact - a highly flexible bench top system based on the bilayer technique. Ionovation Compact opens up a new dimension; the study of membrane channels and transporters from both animal and plant cells and their organelles. No more limitation to suitable cell lines. The response of channel forming proteins to any effector can be investigated, making the Ionovation Compact a powerful tool in pharmacological research, drug discovery, and in academia.
Relevant applications include
- Membrane transport processes
- Searching for active drug substances
- Drug safety
- Signal transduction
- Disease related membrane permeabilisation e.g. parkinson and alzheimer’s disease
The Ionovation Compact addresses the full range from single to multiple channels
- Using purified proteins:
- Unique channel population investigated at a time.
- No background activities.
- Both sides of the channel(s) are easily accessible
- Using membrane preparations:
- Easy approach to whole-cell like investigations
- Both sides of the channel(s) are easily accessible
- Even subcellular compartments / membrane
fragments can be “bilayered”
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