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The Program Committee has scheduled our abstract for the meeting in Los Angeles, California, February 27- March 2, 2016, in a Platform Session in the Los Angeles Convention Center.

Abstract Title:

VIDEO-BASED FORCE DETECTION IN OPTICAL TWEEZERS TO MEASURE DNA TRANSLOCATION THROUGH SI-NX AND LIPID-COATED NANOPORES.

Presenting Author:

Andy Sischka

Platform Session Title:

Platform: Force Spectroscopy and Scanning Probe Microscopy

Date of Presentation:

3/2/2016

Presentation Time:

9:00:00 AM

Location:

Room 515B

Program Number:

2548-Plat

Sensing molecules with light: Ionovation acquires PicoTweezers technology

Ionovation GmbH adds force sensitive optical tweezers to its product portfolio of membrane analysis instruments.

Optical tweezers allow the contact free trapping, moving and manipulating of microscopic objects and biological samples ranging from nanometer to micrometer size, thus offering new possibilities for life and material sciences.

The underlying principle of optical tweezers is that light can trap tiny transparent objects by utilizing the photon’s momentum of a strongly focused laser beam.. If this object changes the direction of the incident light beam it generates an optical trap where it will be securely held.

The object can thus be navigated in a contact-free manner by moving the laser beam with respect to its surroundings.

Detecting and measuring forces that are induced by a variety of molecules acting on the trapped object is the big advantage of the PicoTweezers system, since it allows a vast insight into molecular structures, elasticity, binding properties and kinetics.

Applications for the PicoTweezers system include immobilizing DNA strands as sensors for ligands and receptors, testing polymer elasticity, and the translocation of single or protein-bound DNA strands through artificial and biological nanopores.

"Analyzing biological membranes has been our main focus since we founded the company in 2004, and we are now bringing our technology to the next level ", says Dr. Karsten Gall, CEO of Ionovation GmbH. "With the PicoTweezers setup our customers can now easily study for example the interaction of membrane-embedded nanopores with DNA or RNA, which is crucial for nanopore-based DNA sequencing approaches."

The PicoTweezers system allows quantitative 3D force measurements with sub-pN resolution and generates a maximum trapping force of 400 pN. It utilizes a sophisticated and easy-to-use video analysis for particle tracking, detection and force measurements, thus eliminating common calibration issues and spatial restrictions that other commercial tweezers systems suffer from. "Our PicoTweezers setup offers maximum flexibility for the users because we have installed all the force generating and detecting components of the optical tweezers underneath the sample carrier, thus liberating the space above the experimentation site.", explains Dr. Gall.

Ionovation acquired this new technology from Bielefeld University, Germany, and will offer it as a standalone unit as well as a complement to its Ionovation Explorer set-up. "We have been developing and improving the PicoTweezers technology in our research group for many years and are glad that with Ionovation we have found a commercialization partner with a proven track record for delivering innovations to the market. Ionovation will support the PicoTweezers users with tailored service offers and helps them implementing this exciting technology in their lab.", says Prof. Dario Anselmetti, Department of Experimental Biophysics at Bielefeld University. "We will continue to work closely with Ionovation in all scientific and technical aspects of the PicoTweezers technology."

About Ionovation GmbH

Founded in 2004, Ionovation represents a wealth of experience in the development and application of modern electrophysiological and fluorescence methods, combined with recent additions in the chemical modification molecules to enhance their membrane penetration capabilities. Ionovation's IonoTec product line offers instrumentation, consumables, and services centered on membrane biophysics with instruments for the automated, reproducible, and hence routine-oriented generation of lipid bilayers for the analysis of bio-membrane related phenomena.

 

Contact:

Dr. Karsten Gall
Ionovation GmbH
Westerbreite 7
49084 Osnabrück, Germany
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: +49 (541) 9778-660

 

Meet us at Booth 435

 

Ionovation receives SME Instrument Phase I funding for IonoChem drug delivery system

Osnabrück, August 10, 2015

Ionovation GmbH, a biomembrane research company located in Osnabrück, Germany, was awarded a grant in the highly competitive Horizon2020 SME Instrument Phase I scheme for its innovative trans-membrane drug delivery technology IonoChem.

"In the SME Instrument scheme only the most promising and disruptive technologies are chosen for funding", says Dr. Karsten Gall, CEO of Ionovation GmbH. "We feel very honored; the positive feedback from Brussels shows that it was worth putting in the extra effort for developing a promising new technology that will help us grow beyond our current product line of biomembrane analytical products and services."

With the IonoChem method drugs can be modified to pass through cellular membranes more easily. "Many drugs do not enter cells in sufficient quantities to be effective", explains Professor Helmut Rosemeyer, University of Osnabrück and one of the inventors of the IonoChem method. "With IonoChem we add a lipophilic tail directly to the drug molecule which makes it pass through the membrane more easily. We think that this is a highly promising drug delivery technology especially for RNA and DNA drugs which might have the potential to speed up clinical application of this new class of drugs."

Within this 6 months project Ionovation GmbH will analyze customer needs in depth, refine the business model and will partner with a contract manufacturer as part for preparing for the SME Instrument Phase II grant scheme application.

About Ionovation GmbH

Founded in 2004, Ionovation represents a wealth of experience in the development and application of modern electrophysiological and fluorescence methods, combined with recent additions in the chemical modification of membrane-related molecules. Ionovation's IonoTec product line offers instrumentation, consumables, and services centered on membrane biophysics with instruments for the automated, reproducible, and hence routine-oriented generation of lipid bilayers for the analysis of biomembrane related phenomena. The IonoChem technology offers a broad spectrum of lipids for the lipophilisation of active pharmaceutical ingredients. It comprises various classes of lipids ranging from natural plant origin, like isoprenoids, to functionalised mono- and double tailed natural or (semi-)synthetic lipids. Ionovation GmbH holds the central patent family PCT/EP2013/069936 for this technology.

Contact:

Dr. Karsten Gall
Ionovation GmbH
Westerbreite 7
49084 Osnabrück, Germany
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: +49 (541) 9778-660
 
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 697259.