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Xiaoying Cai, Lei Liu, Chunhong Qiu, Chongzheng Wen, Yao He, Yanxiang Cui, Siyu Li, Xuan Zhang, Longhua Zhang, Changlin Tian, Lijun Bi, Z Hong Zhou, Weimin Gong

Identification and architecture of a putative secretion tube across mycobacterial outer envelope

Sci Adv. 2021 Aug 20;7(34):eabg5656. Print 2021 Aug.

Chen M, Blum D, Engelhard L, Raunser S, Wagner R, Gatsogiannis C

Molecular architecture of black widow spider neurotoxins

Nat Commun. 2021 Nov 29;12(1):6956.

Vassallo N (2021)

Amyloid pores in mitochondrial membranes

Neural Regen Res. 2021 Nov;16(11):2225-2226.

Lin Li et al.

Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

PLOS Genetics | August 29, 2018

Fabiola Wilting, Robin Kopp, Philip A. Gurnev , Anna Schedel, Nathan J. Dupper, Ohyun Kwon, Annette Nicke, Thomas Gudermann, and Johann Schredelseker

The antiarrhythmic compound efsevin directly modulates voltage‐dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca2+ uptake

Br J Pharmacol. 2020 Jul; 177(13): 2947–2958. doi: 10.1111/bph.15022

Tanzir Ahmed, Sander van den Driesche, Jayesh Arun Bafna, Martin Oellers, Roland Hemmler, Karsten Gall, Richard Wagner, Mathias Winterhalter, Michael J. Vellekoop

Rapid lipid bilayer membrane formation on Parylene coated apertures to perform ion channel analyses

Biomedical Microdevices (2020) 22:32.

Malecki, E., Knies, C., Werz, E., Rosemeyer, H.

Mitsunobu Reactions of 5-Fluorouridine with the Terpenols Phytol and Nerol: DNA Building Blocks for a Biomimetic Lipophilization of Nucleic Acids

Chem Biodivers. 2013 Dec;10(12):2209–2220. doi: 10.1002/cbdv.201300107

Weatherill, E., Wallace, M.

Combining Single-Molecule Imaging and Single-Channel Electrophysiology

J Mol Biol. 2015; 427(1):146-157

Wirth A, Jung M, Bies C, Frien M, Tyedmers J, Zimmermann R, Wagner R.

The Sec61p complex is a dynamic precursor activated channel

Mol Cell. 2003; 12(1):261-8

Becker L, Bannwarth M, Meisinger C, Hill K, Model K, Krimmer T, Casadio R, Truscott KN, Schulz GE, Pfanner N, Wagner R.

Preprotein translocase of the outer mitochondrial membrane: reconstituted Tom40 forms a characteristic TOM pore

J Mol Biol. 2005; 353(5):1011-20. Epub 2005 Sep 26.

Hemmler R, Becker T, Schleiff E, Bolter B, Stahl T, Soll J, Gotze TA, Braams S, Wagner R.

Molecular properties of Oep21, an ATP-regulated anion-selective solute channel from the outer chloroplast membrane

J Biol Chem. 2006; 281(17):12020-9. Epub 2006 Feb 10.

Honigmann A, Walter C, Erdmann F, Eggeling C, Wagner R.

Characterization of horizontal lipid bilayers as a model system to study lipid phase separation.

Biophys J. 2010 Jun 16;98(12):2886-94

Erika Kovács-Bogdán, J Philipp Benz, Jürgen Soll, Bettina Bölter

Tic20 forms a channel independent of Tic110 in chloroplasts

BMC Plant Biol. 2011; 11: 133.

Betaneli V, Petrov EP, Schwille P.

The role of lipids in VDAC oligomerization

Biophys J. 2012 Feb 8;102(3):523-31. doi: 10.1016/j.bpj.2011.12.049. Epub 2012 Feb 7.

Wagner M, Blum D, Raschka SL, Nentwig LM, Gertzen CGW, Chen M, Gatsogiannis C, Harris A, Smits SHJ, Wagner R, Schmitt L

A New Twist in ABC Transporter Mediated Multidrug Resistance - Pdr5 is a Drug/proton Co-transporter

J Mol Biol. 2022 Jul 30;434(14):167669. doi: 10.1016/j.jmb.2022.167669. Epub 2022 Jun 6.

Caruana M, Camilleri A, Farrugia MY, Ghio S, Jakubíčková M, Cauchi RJ, Vassallo N (2021)

Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides

Molecules. 2021 Mar 7;26(5):1444. doi: 10.3390/molecules26051444

Zecchi KA and Heimburg T (2021)

Non-linear Conductance, Rectification, and Mechanosensitive Channel Formation of Lipid Membranes.

Front. Cell Dev. Biol. 8:592520. doi: 10.3389/fcell.2020.592520

Maria Ylenia Farrugia, Mario Caruana, Stephanie Ghio, Angelique Camilleri, Claude Farrugia, Ruben J. Cauchi, Sara Cappelli, Fabrizio Chiti & Neville Vassallo

Toxic oligomers of the amyloidogenic HypF‑N protein form pores in mitochondrial membranes

Scientific Reports | (2020) 10:17733 doi: 10.1038/s41598-020-74841-z

Ando T, Bhamidimarri SP, Brending N,  Eggeling C, et al.

The 2018 correlative microscopy techniques roadmap.

J Phys D Appl Phys. 2018 Nov 7;51(44):443001. doi: 10.1088/1361-6463/aad055

Ghio S, Camilleri A, Caruana M, Ruf VC, Schmidt F, Leonov A, Ryazanov S, Griesinger C, Cauchi RJ, Kamp F, Giese A, Vassallo N.

Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes.

ACS Chem Neurosci. 2019 Aug 21;10(8):3815-3829. doi: 10.1021/acschemneuro.9b00320

Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, Leonov A, Ryazanov S, Griesinger C, Giese A, Cauchi RJ, Vassallo N.

Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin.

Biochim Biophys Acta Biomembr. 2019 Sep 12:183064. doi: 10.1016/j.bbamem.2019.183064

Hill K, Model K, Ryan MT, Dietmeier K, Martin F, Wagner R, Pfanner N.

Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment]

Nature. 1998; 395(6701):516-21.

Steinkamp T, Hill K, Hinnah SC, Wagner R, Rohl T, Pohlmeyer K, Soll J.

Identification of the pore-forming region of the outer chloroplast envelope protein OEP16.

J Biol Chem. 2000 Apr 21;275(16):11758-64.

Hill K, Hemmler R, Kovermann P, Calenberg M, Kreimer G, Wagner R.

A Ca(2+)- and voltage-modulated flagellar ion channel is a component of the mechanoshock response in the unicellular green alga Spermatozopsis similis.

Biochim Biophys Acta. 2000; 1466(1-2):187-204.

Goetze TA, Philippar K, Ilkavets I, Soll J, Wagner R.

OEP37 is a new member of the chloroplast outer membrane ion channels

J Biol Chem. 2006; 281(26):17989-98. Epub 2006 Apr 19

Meinecke M, Wagner R, Kovermann P, Guiard B, Mick DU, Hutu DP, Voos W, Truscott KN, Chacinska A, Pfanner N, Rehling P.

Tim50 maintains the permeability barrier of the mitochondrial inner membrane

Science. 2006; 312(5779):1523-6.

Pagliuca C, Goetze TA, Wagner R, Thiel G, Moroni A, Parcej D.

Molecular properties of Kcv, a virus encoded K+ channel.

Biochemistry. 2007; 46(4):1079-90

Werz E, Korneev S, Montilla-Martinez M, Wagner R, Hemmler R, Walter C, Eisfeld J, Gall K, Rosemeyer H.

Specific DNA Duplex Formation at an Artificial Lipid Bilayer: towards a New DNA Biosensor Technology.

Chem Biodivers. 2012; Feb;9(2):272-81

Weiß K, Neef A, Van Q, Kramer S, Gregor I, Enderlein J.

Quantifying the diffusion of membrane proteins and peptides in black lipid membranes with 2-focus fluorescence correlation spectroscopy.

Biophys J. 2013 Jul 16;105(2):455-62. doi: 10.1016/j.bpj.2013.06.004.

Weingarth M, Prokofyev A, van der Cruijsen EA, Nand D, Bonvin AM, Pongs O, Baldus M.

Structural determinants of specific lipid binding to potassium channels.

J Am Chem Soc. 2013 Mar 13;135(10):3983-8. doi: 10.1021/ja3119114. Epub 2013 Mar 4.

Malecki, E., Ottenhaus, V., Werz, E., Knies, C., Martinez, M., Rosemeyer, H.

Nucleolipids of the Cancerostatic 5-Fluorouridine: Synthesis, Adherence to Oligonucleotides, and Incorporation in Artificial Lipid Bilayers

Chem Biodivers. 2014 Feb;11(2):217–232. doi: 10.1002/cbdv.201300127

O. Rauh, U. P. Hansen, D. D. Scheub, G. Thiel & I. Schroeder

Site-specific ion occupation in the selectivity filter causes voltage dependent gating in a viral K+ channel

Scientific Reports | (2018) 8:10406 | DOI:10.1038/s41598-018-28751-w

Ahmed T, Bafna JA, Hemmler R, Gall K, Wagner R, Winterhalter M, Vellekoop MJ, van den Driesche S

Silicon Nitride-Based Micro-Apertures Coated with Parylene for the Investigation of Pore Proteins Fused in Free-Standing Lipid Bilayers

Membranes 2022, 12, 309.

Chaowei Shi, Yao He, Kitty Hendriks, Bert L. de Groot, Xiaoying Cai, Changlin Tian, Adam Lange & Han Sun

A single NaK channel conformation is not enough for non-selective ion conduction

NATURE COMMUNICATIONS | (2018) 9:717 | DOI: 10.1038/s41467-018-03179-y

Qing-Yan Guo, Long-Hua Zhang, Chao Zuo, Dong-Liang Huang, Zhipeng A. Wang, Ji-Shen Zheng, Chang-Lin Tian

Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

Protein Cell (2018)

Rauh O, Hansen UP, Mach S, Hartel AJW, Shepard KL, Thiel G, Schroeder I

Extended beta distributions open the access to fast gating in bilayer experiments: assigning the voltage-dependent gating to the selectivity filter

FEBS Lett. 2017 Dec;591(23):3850-3860 doi: 10.1002/1873-3468.12898

Okazaki, M., Kurabayashi, K., Asanuma, M., Saito, Y., Dodo, K., Sodeoka, M.

VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore
Biochim Biophys Acta. 2015 Sep 22. pii: S0005-2736(15)00302-8.

Thoma L, Dobrowinski H, Finger C, Guezguez J, Linke D, Sepulveda E, Muth G.

A multiprotein DNA translocation complex directs intramycelial plasmid spreading during Streptomyces conjugation.

mBio 6(3):e02559-14. doi:10.1128/mBio.02559-14.

Kovermann P, Truscott KN, Guiard B, Rehling P, Sepuri NB, Muller H, Jensen RE, Wagner R, Pfanner N.

Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel

Mol Cell. 2002; 9(2):363-73

Hinnah SC, Wagner R, Sveshnikova N, Harrer R, Soll J.

The chloroplast protein import channel Toc75: pore properties and interaction with transit peptides

Biophys J. 2002 ;83(2):899-911.

van der Laan M, Meinecke M, Dudek J, Hutu DP, Lind M, Perschil I, Guiard B, Wagner R, Pfanner N, Rehling P.

Motor-free mitochondrial presequence translocase drives membrane integration of preproteins.

Nat Cell Biol. 2007; 9(10):1152-9

Kostka M, H￶gen T, Danzer KM, Levin J, Habeck M, Wirth A, Wagner R, Glabe CG, Finger S, Heinzelmann U, Garidel P, Duan W, Ross CA, Kretzschmar H, Giese A.

Single-particle characterization of iron-induced pore-forming alpha -synuclein oligomers.

J Biol Chem. 2008 Feb 7;

Schneider R, Etzkorn M, Giller K, Daebel V, Eisfeld J, Zweckstetter M, Griesinger C, Becker S, Lange A

The native conformation of the human VDAC1 N terminus.

Angew Chem Int Ed Engl. 2010 Mar 1;49(10):1882-5.

Theis T, Mishra B, von der Ohe M, Loers G, Prondzynski M, Pless O, Blackshear PJ, Schachner M, Kleene R.

Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane.

J Biol Chem. 2013 Mar 1;288(9):6726-42. doi: 10.1074/jbc.M112.444034. Epub 2013 Jan 17.

Köstler K, Werz E, Malecki E, Montilla-Martinez M, Rosemeyer H.

Nucleoterpenes of thymidine and 2'-deoxyinosine: synthons for a biomimetic lipophilization of oligonucleotides

Chem Biodivers. 2013 Jan;10(1):39-61. doi: 10.1002/cbdv.201100338.

Schmidt F, Levin J, Kamp F, Kretzschmar H, Giese A, Bötzel K.

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes.

PLoS One. 2012;7(8):e42545. doi: 10.1371/journal.pone.0042545. Epub 2012 Aug 3.

About us

Ionovation GmbH has a wealth of experience in microscopy and electrophysiology. Our product line includes the 2018 Nobel Prize winning optical tweezers technology as well as unique fluorescence and quantitative phase contrast microscopy in combination with organ-on-chip technologies. In addition, we offer automated workstations for lipid bilayer electrophysiology. We always deliver state-of-the-art technologies and services for your research projects.

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